Background: Opsoclonus-myoclonus syndrome (OMS) is a rare clinical disorder and typically occurs in association\nwith occult neuroblastic tumor in pediatric patients. I-123 metaiodobenzylguanidine (mIBG) scintigraphy is widely\nadopted as screening procedure in patients with suspected neuroblastic tumor. Also, contrast-enhanced magnetic\nresonance imaging (MRI) or computed tomography (CT) are involved in the imaging workup, primarily for the\nassessment of the primary tumor region. However, the diagnostic value of whole-body MRI (WB-MRI) for the\ndetection of occult neuroblastic tumor in pediatric patients presenting with OMS remains unknown.\nCase presentation: We present three cases of patients with OMS, in whom WB-MRI revealed occult neuroblastic\ntumor masses, whereas scintigraphy was inconclusive:\nIn a 17 months old girl with OMS, WB-MRI revealed a paravertebral mass. After thoracoscopic resection,\nhistopathology revealed a ganglioneuroblastoma.\nA 13 months old boy presenting with OMS WB-MRI detected a tumor of the left adrenal gland; histopathology\ndemonstrated a ganglioneuroblastoma after adrenalectomy.\nIn a 2 year old boy with OMS, immunoscintigraphy at the time of diagnosis was inconclusive. At the age of 13\nyears, a WB-MRI was performed due to persistent neurological symptoms, revealing a paravertebral retroperitoneal\nmass, which was classified as ganglioneuroblastoma.\nConclusion: In OMS, particularly in the setting of inconclusive scintigraphy, WB-MRI may be considered as a\nvaluable alternative in the early phase of diagnostic work-up.
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